Chinese Herbal Medicines Intervene in Signaling Pathways Associated with Diabetic Neuropathic Pain： A Review
10.13422/j.cnki.syfjx.20221794
- VernacularTitle:中药干预糖尿病神经痛相关信号通路研究进展
- Author:
Zhijun HE
1
;
Xiaotao WEI
2
;
Yuchang ZHANG
1
;
Tao LIU
1
;
Weiwei WANG
2
Author Information
1. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China
2. Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
diabetic neuropathic pain （DNP）;
signaling pathway;
Chinese medicine;
Chinese herbal medicines;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(17):275-282
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic neuropathic pain （DNP） is one of the common complications of diabetic peripheral neuropathy， which is difficult to be cured. The clinical manifestations of DNP include reduced pain threshold， neuropathic pain in extremities， and abnormal pain. Studies have demonstrated that nuclear factor-kappa B （NF-κB）， mitogen-activated protein kinase （MAPK）， Toll-like receptor 4 （TLR4）， nuclear factor erythroid 2-related factor 2 （Nrf2）， and phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathways are involved in the treatment of DNP by inhibiting the activation and release of inflammatory cytokines ［e.g.， tumor necrosis factor-alpha （TNF-α） and interleukin （IL）］， regulating inflammation-mediating factors ［e.g.， reactive oxygen （ROS）， inducible nitric oxide synthase （iNOS）， cyclooxygenase （COX-2）， and NF-κB inhibitor （IκB）］， suppressing neurogenic inflammation， destroying the persistent damage of peripheral nerves， and repairing damaged peripheral nerves. The literature of modern medical research has demonstrated that the treatment of DNP with Chinese herbal medicines is associated with the signaling pathways above. They can treat DNP by regulating the expression of key proteins in the signaling pathways to control neurogenic inflammation and repair diabetic peripheral neuropathic damage. By summarizing the available studies， this review aims to provide a reference for the in-depth research on Chinese herbal medicines in the treatment of DNP and give new insights into the protection of diabetic peripheral nerves and the treatment of DNP with Chinese herbal medicines.
