Chinese Medicine Monomers Regulate Atherosclerosis Through NF-κB Pathway： A Review
10.13422/j.cnki.syfjx.202201004
- VernacularTitle:中药单体通过NF-κB信号通路防治动脉粥样硬化研究进展
- Author:
Jianglong FU
1
;
Xue YANG
1
;
Wanruo WAN
1
;
Fan ZHANG
1
;
Xiaotao HOU
1
;
Jiagang DENG
1
;
Erwei HAO
1
Author Information
1. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica，Guangxi Collaborative Innovation Center of Research on Functional Ingredients of Agricultural Residues，Guangxi Key Laboratory of Traditional Chinese Medicine Formulas Theory and Transformation for Damp Diseases， Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Review
- Keywords:
atherosclerosis;
nuclear transcription factor-kappa B （NF-κB）;
Chinese medicine;
inflammation;
Chinese medicine monomer
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(17):195-208
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are the leading cause of death in the world today. Atherosclerosis （AS） is a chronic inflammatory disease characterized by thickening or functional degeneration of the arterial wall， and in the later stage of the disease， plaque ruptures to induce thrombosis， which in turn causes ischemia in tissues or organs. It is therefore the pathological basis for all types of cardiovascular diseases. Nuclear transcription factor kappa B （NF-κB）， an important nuclear transcription factor in the inflammatory response， is activated to mediate the transcription of inflammatory factors that can trigger or exacerbate the development of AS. Vascular endothelial cells are activated by inflammatory factors. NF-κB mediates related regulatory genes in endothelial cells to secrete adhesion molecules， chemokines， and coagulation factors， promotes selective aggregation of monocytes， up-regulates the expression of adhesion molecules to make adhesion molecules stick to the endothelium and move toward the intima， promotes the degradation of the extracellular matrix， and forms unstable plaques. In recent years， traditional Chinese medicine （TCM） has achieved certain results in the prevention and treatment of AS， and many Chinese medicines have been proved to be effective in resisting AS and can act on multiple targets in the human body， affecting the occurrence and development of AS in different links. This paper mainly introduced the NF-κB pathway and its relationship with AS， reviewed research progress on 75 components of different types in Chinese medicine monomers such as flavonoids， terpenoids， and alkaloids in AS resistance based on the NF-κB pathway， and found that Chinese medicine monomers mainly regulate cholesterol balance， inhibit the inflammatory response， reduce cell proliferation， inhibit intercellular adhesion， and suppress foam cell formation by regulating the NF-κB pathway to provide a reference for the prevention and treatment of AS.
