Intervention of Hei Xiaoyaosan in Alzheimer's Disease Immune Inflammation Based on Liver-kidney Homology
10.13422/j.cnki.syfjx.20221791
- VernacularTitle:从“肝肾同调”探析黑逍遥散干预AD免疫炎症的研究思路
- Author:
Huping WANG
1
;
Caiyun MI
1
;
Jun ZHOU
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Hei Xiaoyaosan;
research ideas;
liver-kidney homology;
immune inflammation;
signal pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(17):180-187
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease （AD） is a neurological disease highly related to age， which is the main cause of senile dementia and the most common disease leading to the loss of daily living ability of the elderly. AD brings heavy mental burden and economic pressure to patients， families， and society. Traditional Chinese medicine （TCM） ascribes AD to category of "dementia"， believing that the treatment should start from kidney because kidney deficiency is the root cause. Combined with the physiological and pathological characteristics of liver， this paper proposed that liver-kidney homology was an important idea for the prevention and treatment of AD. The main pathological manifestations of AD were amyloid β-protein （Aβ） deposition and neurofibrillary tangles （NFT）， and the pathogenesis was complex. A growing number of studies showed that immune inflammation played an important role in the pathogenesis of AD. The important target of treating AD was the regulation of neuro-immune inflammation through the nuclear factor kappa B （NF-κB）/NOD-like receptor thermal protein domain associated protein 3 （NLRP3）/Caspase-1/interleukin-1β （IL-1β） signaling pathway. Based on the idea of liver-kidney homology， this paper selected the representative formula Hei Xiaoyaosan to explore its effect on the prevention and treatment of AD and the mechanism from the perspective of regulating NF-κB/NLRP3/Caspase-1/IL-1β signaling pathway and inhibiting neuro-immune inflammation， expecting to further promote the in-depth study on the prevention and treatment of AD， and provide references for the prevention and treatment of AD by TCM.
