A Case of Furosemide Induced Acute Interstitial Nephritis.
- Author:
Kuk Hee IM
;
Young Ok KIM
;
Soon Hwa HONG
;
Jae Myoung PARK
;
Sun Ae YOON
;
Yong Soo KIM
;
Eun Sun JUNG
;
Kyung Ah CHUN
;
Byung Kee BANG
- Publication Type:Case Report
- Keywords:
Acute interstitial nephritis;
Acute renal failure;
Furosemide;
Skin rash
- MeSH:
Acute Kidney Injury;
Adult;
Atrophy;
Biopsy;
Creatinine;
Dermatitis;
Diuretics;
Eosinophilia;
Exanthema;
Female;
Fibrosis;
Furosemide*;
Humans;
Methicillin;
Nephritis, Interstitial*;
Skin;
Vasculitis
- From:Korean Journal of Nephrology
1998;17(6):973-977
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug-induced acute interstitial nephritis is characterized by renal interstitial inflammatory cell infiltration and commonly presents as acute renal failure. This is caused mainly by methicillin, non-steroidal antiinflammatory drugs, sulfonamide diuretics such as thiazide, but cases induced by furosemide are rare. We report a patient with acute interstitial nephritis causing reversible acute renal failure and dermatitis while she was taking furosemide. A 37-year old woman was referred to our hospital because of generalized skin rash and non-oliguric acute renal failure. She had peripheral eosinophilia (1,577/mm3) and serum creatinine level of 6.8mg/dL. Skin biopsy showed leukoclastic vasculitis and percutaneous renal biopsy showed severe interstitial infiltration of lymph ocyte and mild interstitial fibrosis with focal tubular atrophy. After withdrawal of furosemide, renal function and skin lesions were completely recovered.
