Classical Famous Prescription Zhenwutang in Treatment of Chronic Heart Failure： A Review
10.13422/j.cnki.syfjx.20221399
- VernacularTitle:经典名方真武汤治疗慢性心力衰竭的研究现状
- Author:
Zhuhui ZHANG
1
;
Cheng CHEN
2
;
Jianhe LIU
3
;
Jiao CAO
1
;
Shuaishuai XIA
1
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
2. Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine（TCM），Huangpu Hospital of Guangdong Second TCM Hospital，Guangzhou 510530，China
3. Sub-center of National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine，The First Hospital of Hunan University of Chinese Medicine，Changsha 410007，China
- Publication Type:Review
- Keywords:
Zhenwutang;
chronic heart failure;
mechanism;
clinical applications;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(13):242-249
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure （CHF）， the end stage of heart disease due to a variety of causes， features high disability rate and mortality， which has become a hot spot in cardiovascular field. As recorded in Treatise on Cold Damage（《伤寒论》）， Zhenwutang is composed of Radix Aconiti Lateralis Preparata， Poria Cocos， Rhizoma Atractylodis Macrocephalae， Paeoniae Radix Alba， and Rhizoma Zingiberis Recens. With the functions of warming Yang and excreting water， it is a classical prescription for the treatment of CHF in clinical settings. By searching China National Knowledge Infrastructure （CNKI）， PubMed， Wanfang Data， and VIP， we find Zhenwutang exerts therapeutic effect on CHF through multiple targets and multiple pathways. Experiments show that it alleviates CHF by antagonizing the overactivation of neuroendocrine system， inhibiting immune-inflammatory response， suppressing cardiac remodeling， restricting apoptosis， regulating autophagy， improving myocardial energy metabolism， inhibiting oxidative stress injury， protecting endothelial function， and decreasing volume load. Clinical research shows that Zhenwutang can significantly alleviate the clinical symptoms of CHF patients in a safe manner with little adverse reactions. This paper systematically summarizes the mechanisms of and clinical research on Zhenwutang in the treatment of CHF in recent years， so as to provide theoretical and experimental data for the further research and development of Zhenwutang.
