Discussion on Material Basis of Different Parts of Mulberry with Different Effects Based on Molecular Connectivity Index
10.13422/j.cnki.syfjx.20211858
- VernacularTitle:基于分子连接性指数探讨桑源药材不同入药部位“异效”的物质基础
- Author:
Yuefeng WU
1
;
Zhifei ZHU
1
;
Jinling LIU
1
;
Qimeng FAN
1
;
Youzhi LIU
1
;
Jin ZHOU
1
;
Fuyuan HE
1
Author Information
1. School of Pharmacy，Hunan University of Chinese Medicine，Hunan Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine，Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization for Chinese Materia Medica，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
mulberry;
mulberry-source medicinal materials;
homologous and heterologous effects;
molecular connectivity index;
core index;
quality marker;
material basis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(13):152-160
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the material basis for the difference in the efficacy of different parts of mulberry based on molecular connectivity index （MCI）. MethodBy referring to the relevant literature at home and abroad and traditional Chinese medicine systems pharmacology database and analysis platform （TCMSP） database， the chemical composition database of mulberry-source medicinal materials was established. Venn analysis was carried out on the components among mulberry-source medicinal materials. The components in the database were divided into 10 categories， and the composition information was analyzed. According to MCI value， all components of mulberry-source medicinal materials were divided into different groups. The angle cosine method was used to calculate the MCI similarity. The average MCI values of the common component group from 0-8 orders and CI of mulberry-source medicinal materials were calculated. ResultThe components with high similarity such as （+）-cycloolivil， 1′-methoxy-2′-hydroxydihydromollugin， kuwanon， morusin and 1-deoxynojirimycin were selected as potential pharmacodynamic components. Mulberry-source medicinal materials could be divided into five component groups. The similarity between component groups and total components was 0.760-0.999， and the similarity between component groups was 0.248-0.999. In Mori Ramulus， Mori Folium， Mori Cortex and Mori Fructus， the average MCI values of their flavonoids from 0-8 orders were 4.57， 4.59， 6.41， 4.24， respectively. The average MCI values of alkaloids from 0-8 orders were 2.65， 4.55， 2.58， 2.78， respectively. The average CI values from 0-8 orders were 5.51， 5.49， 5.44 and 2.88， respectively. ConclusionIt is preliminarily concluded that there are differences in the flavonoids and pathways of hypoglycemic effects between Mori Cortex and the other three mulberry-source medicinal materials. The MCI values of alkaloids from 0-8 orders in Mori Folium and Mori Fructus were higher， but their inhibitory activity of α-glucosidase were lower than those of Mori Ramulus and Mori Cortex. The structural characteristics of the total components of Mori Fructus represented by CI were quite different from the other three mulberry-source medicinal materials.
