Traditional Chinese Medicine Intervention of Ferroptosis Based on Yin-yang Theory： A Review
10.13422/j.cnki.syfjx.20220504
- VernacularTitle:基于阴阳理论探讨中医药干预铁死亡的研究进展
- Author:
Yang YANG
1
;
Yuan-yuan ZHONG
2
;
Chang SU
1
;
Qiu-yan ZHANG
1
;
Meng YANG
1
;
Xiang-zhuo ZHANG
1
;
Shu-chun HUANG
1
;
Hui-fang KUANG
1
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
2. Huashan Hospital，Fudan University，Shanghai 200433，China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
traditional Chinese medicine;
Yin-yang theory;
damaging the excess;
compensating the deficiency
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(11):227-237
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis， a new type of iron-dependent programmed cell death， is related to multiple pathways such as glutathione/glutathione peroxidase 4， iron metabolism， lipid metabolism， and iron autophagy， and plays an important part in the occurrence and development of many diseases， such as tumor， cerebral ischemia， and Parkinson's disease. Ferroptosis is a double-edged sword as it can eliminate pathological cells （such as tumor cells） but long-term ferroptosis may cause or aggravate other disorders related to abnormal lipid metabolism and iron metabolism. Regulating the balance between cell proliferation and ferroptosis may be an important target for drug intervention in diseases. The Yin-yang theory is one of the foundational principles of traditional Chinese medicine （TCM）， which is used to explain the physiological functions and pathological changes of human body and to guide the diagnosis and prevention of disease and health care. The balance of cell proliferation and programmed death is essentially the balance of Yin and Yang at the cellular level， which is governed and regulated by the law of balance. TCM intervenes in ferroptosis by promoting ferroptosis of tumor cells （damaging the excess） and inhibiting ferroptosis of other diseases （compensating the deficiency）， which is similar to the treatment principle of adjusting Yin and Yang. On this basis， this article aims to use the Yin-yang theory to clarify the relationship between TCM promoting ferroptosis and inhibiting ferroptosis， which is expected to lay a basis for the modern application of Yin-yang theory and provide new targets for TCM treatment.
