Photodynamic Therapy for Chronic Central Serous Chorioretinopathy According to Degree of Choroidal Hyperfluorescence.
10.3341/jkos.2012.53.2.268
- Author:
Su Ho LIM
1
;
Woo Hyok CHANG
;
Min SAGONG
Author Information
1. Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. msagong@ynu.ac.kr
- Publication Type:Original Article
- Keywords:
Chronic central serous chorioretinopathy;
Indocyanine green angiography;
Photodynamic therapy
- MeSH:
Angiography;
Central Serous Chorioretinopathy;
Choroid;
Eye;
Follow-Up Studies;
Humans;
Indocyanine Green;
Photochemotherapy;
Recurrence;
Subretinal Fluid;
Triazenes;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2012;53(2):268-275
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare the efficacy of photodynamic therapy (PDT) depending on the degree of hyperfluorescence based on indocyanine green angiography (ICGA) for treating chronic central serous chorioretinopathy (CSC). METHODS: Twenty-three eyes of 23 patients with chronic CSC were recruited for the present study. The minimum follow-up period was six months. The total energy of PDT was reduced to 25 J/cm2 for 83 seconds. The baseline middle-phase ICGA findings were classified as intense or low hyperfluorescence depending on the degree of hyperpermeability from choriocapillaris. The change in mean best-corrected visual acuity, the resolution of subretinal fluid, recurrence rate, and complication were analyzed in relation to each ICGA finding at baseline. RESULTS: The baseline ICGA findings showed intense hyperfluorescence in 11 eyes (47.8%) and low hyperfluorescence in 12 eyes (52.2%). The subretinal fluid resolved completely one month after a single application of low-fluence PDT in both groups. The subretinal fluid recurred in one of 12 eyes (8.3%) with low hyperfluorescence and in no eyes (0%) with intense hyperfluorescence. There was no statistically significant difference in the rate of recurrence between the two groups. CONCLUSIONS: Low-fluence PDT appears to be an effective and safe treatment option for long-standing chronic CSC regardless of the degree of hyperfluorescence based on the ICGA.
