Roles of Pyroptosis and Necroptosis in Diabetic Kidney Disease and Its Regulation with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20220336
- VernacularTitle:细胞焦亡与坏死性凋亡在糖尿病肾病中的作用及中医药干预研究进展
- Author:
He-chao JIN
1
;
Yue GU
1
;
Yuan-yuan ZHANG
1
;
Si-yu WANG
1
;
Lan-ge JI
1
;
Deng-zhou GUO
1
Author Information
1. Hebei University of Chinese Medicine，Shijiazhuang 050200，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease （DKD）;
pyroptosis;
necroptosis;
inflammation;
traditional Chinese medicine （TCM）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(3):58-67
- CountryChina
- Language:Chinese
-
Abstract:
The increasing incidence of obesity and diabetes has made diabetic kidney disease （DKD） the main cause of chronic kidney disease and end-stage renal disease. Despite current pharmacological interventions for blood glucose control and renin-angiotensin system inhibition， the risk of kidney disease progression and complications remains high. At present， the pathogenesis of DKD has been clarified to be related to chronic inflammatory response， oxidative stress， glucose and lipid metabolism disorders， and hemodynamic abnormalities. According to recent studies， the programmed cell deaths （PCD） of renal intrinsic cells such as pyroptosis and necroptosis play a key role in the occurrence and development of DKD. Pyroptosis and necroptosis， the two newly discovered routes of PCD， can protect the hosts from being invaded by microbial pathogens， but their dysregulation is associated with multiple autoimmunity and autoinflammatory responses. Pyroptosis and necroptosis are closely interlinked and cross-regulated. Different from apoptosis， these two cellular suicide mechanisms cause membrane rupture and release of cell contents through their respective gasdermin D （GSDMD） and mixed lineage kinase domain-like protein （MLKL）， with damage-associated molecular patterns （DAMPs） and inflammatory cytokines like interleukin-1β （IL-1β） involved to trigger inflammation， and chronic inflammatory responses are key factors leading to the progression of DKD. Traditional Chinese medicine （TCM） has long been employed for the prevention and treatment of DKD and the resulting clinical outcomes are remarkable. TCM has been proved to exert a protective effect against DKD by affecting the expression of nucleotide oligomerization domain-like receptor protein 3 （NLRP3） inflammasome， receptor-interacting protein kinase 3 （RIPK3）， and MLKL. This paper reviewed the relationship of pyroptosis and necroptosis with DKD and its intervention with TCM.
