Clinical Randomized Controlled Observation of Modified Wuhutang in Treatment of Acute Asthma in Children
10.13422/j.cnki.syfjx.20220425
- VernacularTitle:五虎汤加味治疗儿童哮喘急性发作期痰热阻肺证的临床随机对照观察
- Author:
Lin-lin YU
1
;
Jing WANG
1
;
Zhi-qi YE
1
;
Rong LU
1
;
Xiao-ping JING
1
Author Information
1. Children′s Hospital of Shanghai， Children′s Hospital of Shanghai Jiaotong University， Shanghai 200040， China
- Publication Type:Journal Article
- Keywords:
childhood asthma;
acute exacerbation;
modified Wuhutang;
clinical research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(5):95-101
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical effect of modified Wuhutang in the treatment of children with acute asthma. MethodA total of 130 children with acute asthma were randomly divided into an observation group and a control group， with 65 cases in each group. The observation group was treated with modified Wuhutang and the control group was treated with procaterol hydrochloride for one week. The scores of primary symptoms （wheezing， cough， shortness of breath， and chest tightness） and secondary symptoms （mental status， runny nose， dry mouth， tongue texture， tongue coating， stool， etc.）， lung functions， immunoglobulin E （IgE） expression， eosinophil （EOS） count， and serum inflammatory factors， including interleukin （IL）-5， IL-6， IL-8， and IL-1β in two groups before and after treatment were compared. ResultThe data of 126 children were statistically analyzed. As revealed by the results， compared with the conditions before treatment， the scores of primary symptoms and secondary symptoms， serum levels of IL， IgE expression， and EOS count were both reduced in two groups （P<0.05）， lung functions were increased in the two groups（P<0.05）. Compared with the control group after treatment， the observation group showed decreased scores of cough and secondary symptoms （P<0.05）， and insignificant decrease in IL-1β （P<0.05）. The improvement in lung functions， IgE expression， and EOS count in observation group was equivalent to that in control group. ConclusionModified Wuhutang for treatment of acute asthma in children （phlegm-heat obstructing lung syndrome） can significantly relieve the clinical symptoms， improve lung functions， and reduce IgE， IL-5， IL-6， IL-8， IL-1β expression levels and EOS count， and its overall clinical efficacy is superior or equivalent to that of tprocaterol hydrochloride.
