Pharmacological Effect and Mechanism of Andrographolide： A Review
10.13422/j.cnki.syfjx.20220306
- VernacularTitle:穿心莲内酯药理作用及机制研究进展
- Author:
Hui-zhen QIN
1
;
Si LIN
1
;
Ling-yu DENG
1
;
Feng-feng XIE
1
;
Miao ZHANG
1
;
Hua ZHU
1
;
Long CHEN
1
Author Information
1. Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
andrographolide;
anti-inflammation;
anti-tumor;
pharmacological effect;
signaling pathways;
molecular mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(6):272-282
- CountryChina
- Language:Chinese
-
Abstract:
Andrographolide， a diterpene lactone， is the important material basis for the pharmacological effect of the Chinese medicinal Andrographis paniculata （Burm.f.）Nees. Modern pharmacological research has shown that andrographolide has many pharmacological activities such as anti-inflammation， bacteriostat， anti-virus， anti-tumor， protecting liver， promoting the function of gallbladder， and protecting the cardiovascular system and nervous system. It has significant anti-inflammatory activity which involves multiple targets. To be specific， it can inhibit nuclear factor-κB （NF-κB）， signal transduction and activator of transcription 3 （STAT3）， and other signaling pathways， reduce the synthesis and release of downstream inflammatory mediators， and regulate oxidative stress and immune response to achieve anti-inflammatory effect on various inflammatory diseases. At the same time， it suppresses a variety of tumor cells by inhibiting tumor cell proliferation， blocking cell cycle， and inducing tumor cell apoptosis. Its anti-tumor mechanism involves cellular signaling pathways such as Notch， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， NF-κB， and secreted glycoprotein/β-catenin （Wnt/β-catenin）. In addition， it can also alleviate diabetes by regulating glucose metabolism. According to related research， it often exerts pharmacological effects through multiple pathways and multiple targets， but the specific targets are unclear. Therefore， this article summarizes the relevant studies on the pharmacological effects and mechanisms of andrographolide in the past three years and puts forward the future research directions， which is expected to serve as a reference for the further in-depth research and development and utilization of andrographolide.
