Relationship Between Intestinal Flora and Bone and Joint Diseases and Regulation of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20220792
- VernacularTitle:肠道菌群与骨关节疾病的关系及中医药调节研究进展
- Author:
Hui LI
1
;
Xing-wen XIE
2
;
Ning LI
1
;
Jian-guo LI
2
;
Ding-peng LI
2
;
Ju-xian DING
2
;
Bo LIU
2
;
Peng-fei LUO
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Second Provincial People's Hospital of Gansu，Affiliated Hospital of Northwest Minzu University，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
intestinal flora;
traditional Chinese medicine;
osteoporosis;
osteoarthritis;
rheumatoid;
gout
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(7):268-275
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal flora is the largest microbial community in human body， which consists of more than 1 000 species. Its structure and metabolites change dynamically with the age， diet and intestinal environment of the host. Study shows that the intestinal microbes play a pivotal role in regulating human physiological and pathological processes， and intestinal flora imbalance may be the key factors affecting the occurrence and development of bone and joint diseases， including osteoporosis， osteoarthritis， rheumatoid arthritis and gouty arthritis. At present， calcitonin， estrogen， nonsteroidal anti-inflammatory drugs， immunosuppressants， xanthine oxidase inhibitors and other western drugs are mostly used to treat the above diseases. However， long-term use of western drugs leads to poor compliance and obvious gastrointestinal adverse reactions among patients. Traditional Chinese medicine （TCM） predominates in the treatment of bone and joint diseases due to its low price， high efficacy and slight side effects， with the advantages of multi-targets， multi-mechanism and multi-levels. In recent years， many scholars have carried out experiments and clinical studies on the treatment of bone and joint diseases by TCMs on the basis of the liver and kidney theory such as "tonifying liver and kidney and strengthening muscles and bones". Gratifying results have been achieved. However， the mechanism of action has not been fully clarified. Intestinal flora becomes a hot spot in medical research， and a close relationship between intestinal flora and bone and joint diseases has been unveiled. Relevant literature in China and abroad showed that TCM has a significant effect on the treatment of bone and joint diseases by regulating intestinal flora. In this paper， the relationship between intestinal flora and bone and joint diseases was summarized and the intervention of TCM active ingredients and compounds on intestinal flora was reviewed to facilitate the prevention and treatment of bone and joint diseases by TCM.
