Application and Prospect Analysis of Preparation Technology in Improving Antibacterial Activity of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20211766
- VernacularTitle:制剂技术在提高中药抗菌活性方面的应用及前景分析
- Author:
Chen CHEN
1
;
Yong-yuan LI
1
;
Hai-xia WANG
1
;
Ze-shuai ZHANG
1
;
Zheng LI
1
;
Tong-chuan SUO
1
;
Xin-bo SONG
1
;
Ping WANG
2
Author Information
1. College of Pharmaceutical Engineering of Traditional Chinese Medicine （TCM）， Tianjin University of TCM，Tianjin 301617，China
2. Tianjin Modern Innovation TCM Technology Co. Ltd.，Tianjin 300392，China
- Publication Type:Journal Article
- Keywords:
bacterial infection;
preparation technology;
antibacterial activity;
Chinese materia medica;
nanotechnology;
3D printing;
electrospinning
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(7):247-253
- CountryChina
- Language:Chinese
-
Abstract:
Pathogenic bacterial infection is one of the main clinical symptoms. Antibiotics are widely used in clinical practice to inhibit or kill the bacteria， fungi and other pathogenic microorganisms. However， with the massive use of antibiotics， drug-resistant strains continue to appear that make the antibacterial situation is becoming increasingly severe. Due to the advantages of multiple targets， multiple pathways and multiple components， traditional Chinese medicine （TCM） have gradually attracted more attention and were used in antibacterial treatment. However， some antimicrobial TCM have problems such as low solubility， poor stability， and low bioavailability. Improving and enhancing the antibacterial activity of TCM through preparation technology is one of the effective solutions. Based on this， two aspects of unilateral antibacterial TCM preparation technology and combination antibacterial preparation technology are introduced， including inclusion technology， nanotechnology， electrospinning， 3D printing and others. Distinctive features and specific application effects of these preparation technologies are explained firstly， and then their advantages and disadvantages are compared and analyzed. The review can be a useful reference for improving the antibacterial activity of TCM.
