Bazi Bushen Capsules on Anti-aging： A Review
10.13422/j.cnki.syfjx.20220349
- VernacularTitle:八子补肾胶囊的抗衰老研究进展
- Author:
Hong-rong LI
1
;
Cong WEI
1
;
Chuan-yuan JI
1
;
Xin-jing MAO
1
;
Dan-dong WANG
1
;
Kun MA
2
;
Jing AI
3
;
Yun-long HOU
1
;
Zhen-hua JIA
1
Author Information
1. National Key Laboratory of Luobing Research and Innovative Chinese Medicine，Key Laboratory of Cardio-cerebral Vessel Collateral Disease of National Administration of Traditional Chinese Medicine， Hebei Institute of Integrated Traditional Chinese and Western Medicine，Shijiazhuang 050035，China
2. Hebei Yiling Hospital，Shijiazhuang 050091，China
3. School of Pharmacy，Harbin Medical University，Harbin 150086，China
- Publication Type:Journal Article
- Keywords:
anti-aging;
Qiluo doctrine;
essence， Qi and spirit theory;
Bazi Bushen capsules;
senile diseases;
pharmacological effects;
clinical trials
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(7):239-246
- CountryChina
- Language:Chinese
-
Abstract:
The decline of body function and senile diseases caused by aging seriously affect human health and life span， which is an important topic in the field of life science. Bazi Bushen capsules is a representative Chinese patent medicine for tonifying essence， invigorating Qi and anti-aging， guided by Qiluo doctrine， and essence， Qi and spirit theory. Previous pharmacological and clinical studies have confirmed that this preparation has the comprehensive advantages of anti-aging， and prevention and treatment of aging-related diseases. Among them， pharmacological studies showed that Bazi Bushen capsules had the effect of improving the appearance status of mice， improving the level of sex hormones， inhibiting the formation of atherosclerosis， improving cardiac function， improving learning and memory cognitive ability， improving neurological function， improving osteoporosis and muscle function， improving sperm count and quality. The mechanism was related to the up-regulation of the recombinant sirtuin （SIRT6） level， down-regulation of the levels of aging-related proteins p53 and p16， up-regulation of telomerase reverse transcriptase level， and alleviation of inflammation and oxidative response. Clinical studies have proved that it can improve the symptoms of patients with kidney essence deficiency， improve exercise ability， and improve the sexual function of impotence patients. Anti-aging research of Bazi Bushen capsules based on Qiluo doctrine fully embodies the new mode of academic innovation and transformation of traditional Chinese medicine （TCM） with the combination of "theory-new drug-experiment-clinic"， which has made a demonstration for the anti-aging research of TCM.
