Exploration of Ideas and Strategies for TCM Modernization Experimental Research Based on Precise Messenger Targeting of Exosomes and TCM Supramolecular "Qi Chromatography" Theory
10.13422/j.cnki.syfjx.20211846
- VernacularTitle:基于外泌体的精准信使靶向性和中医药超分子“气析”理论的中医药现代化实验研究思路与策略探索
- Author:
Ding-fang CHEN
1
;
Yue-feng WU
1
;
Hai-ying LI
1
;
Kai-wen DENG
1
;
Lei MENG
1
;
Ren WANG
1
;
Mei-feng XIAO
1
;
Yi-qun ZHOU
1
;
Xue PAN
1
;
Fu-yuan HE
1
Author Information
1. School of Pharmacy，Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine，Supramolecular Mechanism and Mathematic-physics Chracterization for Chinese Materia Medica，Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
exosomes;
theory of traditional Chinese medicine;
imprinting templates;
supramolecular "Qi chromatography" theory;
targeting;
targeted preparations;
formula compatibility
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(7):198-206
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are lipid bilayer membranous vesicles actively secreted by various cells in the organism， which are like nanoparticles and have messenger targeting. Combining with the theory of supramolecular "Qi chromatography" of traditional Chinese medicine （TCM）， research ideas and strategies of modernization of TCM can be constructed. Exosomes are secreted by cells， and the membrane contains nucleic acids， proteins， lipids and small molecular metabolites and others， which can accurately coordinate the functions of each cell， concentrate and transmit the functional information of the parent cell， and is the concise form of reflecting cell functions. At the same time， it is loaded with the "imprinted templates" of the supramolecular "Qi chromatography" theory of TCM. If the "imprinted templates" carrying rules among the gene-protein-lipid-small molecules wrapped in it is studied， the modern experimental research ideas and strategies of TCM theory can be established for revealing the functions of the body's meridians and viscera. Firstly， the present situation of exosomes， including discovery， secretion， characteristics， functions， attribution， uptake， research methods and application status， were reviewed in this paper. And the natural properties of its precise messenger targeted delivery vehicle were elaborated， reflecting the operation law of microscopic substances in meridians and viscera. Secondly， to explore it as an important carrier of the concentrated "imprinted templates" of the supramolecular "Qi chromatography" theory of TCM， and integrating the research methods of exosomes and supramolecular chemistry of TCM， this paper proposes experimental research ideas and strategies on the microscopic material basis of meridians and viscera， compatibility of TCM compound， and targeting of TCM targeted preparations.
