A Case of Adult T-cell Leukemia/Lymphoma.
- Author:
Jin Young JUNG
1
;
Hee Jung LEE
;
Ju Hee LEE
;
Kwang Hoon LEE
Author Information
1. Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. kwanglee@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Adult T-cell leukemia/lymphoma;
HTLV-I
- MeSH:
Adult*;
Antibodies;
Biopsy;
Diagnosis;
DNA;
Drug Therapy, Combination;
Human T-lymphotropic virus 1;
Humans;
Hypercalcemia;
Interferon-alpha;
Leukemia;
Leukemia, T-Cell;
Leukemia-Lymphoma, Adult T-Cell;
Leukocyte Count;
Lymph Nodes;
Lymphatic Diseases;
Lymphocytes;
Lymphoma, T-Cell;
Melena;
Middle Aged;
Physical Examination;
Proviruses;
Skin;
Stomach;
T-Lymphocytes*;
Zidovudine
- From:Korean Journal of Dermatology
2007;45(1):58-62
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Adult T-cell leukemia/lymphoma (ATLL) is a human malignancy associated with human T-cell leukemia virus type I (HTLV-I), which frequently involves the skin. ATLL can be diagnosed based on clinicopathological findings and the presence of anti-HTLV-I serum antibodies and monoclonal integrated HTLV-I provirus in the DNA of tumor cells. It is characterized by leukemia, lymphadenopathy, hypercalcemia, and lytic bone lesions. We report a case of ATLL in a 59-year-old man who developed multiple, scattered papules on the face and trunk. He had a 3-month history of melena. The physical examination showed multiple cervical and axillary lymph node enlargements. On laboratory investigation, the white blood cell count was 113,900/mm(3) with 70% atypical lymphocytes. Histopathological and immunohistochemical analyses of a skin and stomach biopsy confirmed the diagnosis of T-cell lymphoma. Final diagnosis of ATLL was made based on HTLV-I positivity. The patient underwent multiple cycles of combination chemotherapy and combination therapy of zidovudine and interferon-alpha which produced some improvement, but he died of pulmonary complications 3 months after the initial diagnosis.
