TCM Intervention in Progression of Esophageal Precancerous Lesions into Esophageal Cancer： A Review
10.13422/j.cnki.syfjx.20220996
- VernacularTitle:中医药干预食管癌前病变转癌相关研究进展
- Author:
Fei SU
1
;
Li-qun JIA
1
;
Zhi-qiang CHENG
1
;
Chao DENG
1
;
Yan-ni LOU
1
Author Information
1. China-Japan Friendship Hospital，Beijing 100029，China
- Publication Type:Journal Article
- Keywords:
esophageal intraepithelial neoplasia;
esophageal cancer;
early prevention;
traditional Chinese medicine（TCM） therapy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(9):242-247
- CountryChina
- Language:Chinese
-
Abstract:
China has a high incidence of esophageal cancer，more than 90% of which are esophageal squamous cell carcinoma （ESCC）. Abnormal proliferation，migration and new microvessels of intraepithelial neoplasia cells are the important pathogenic links in the transformation from esophageal intraepithelial neoplasia （EIN） to ESCC. Studies on the progression of esophageal precancerous lesions into esophageal cancer mostly focus on environment and genetic susceptibility，such as inflammatory factors，abnormal vascular endothelial growth factor （VEGF） signaling pathway transduction，p53 gene mutation，and DNA methylation. Some pharmacology studies have confirmed that traditional Chinese medicine （TCM） can inhibit inflammatory factors，regulate abnormal signaling pathways and improve the microenvironment. A large number of patients with esophageal cancer have been found to be in advanced stage，and the 5-year survival rate is low even after active treatment. The quality of life of patients in advanced stage is worrying due to esophageal obstruction and lung infection，and therefore， early prevention is important. Early intervention in patients with esophageal precancerous lesions is in line with clinical needs and embodies the TCM theory of “treating disease before its onset.” The mechanism of action and clinical efficacy of TCM has been gradually confirmed and promoted， with certain clinical significance. To explore simple，economical and effective TCM intervention measures conforms to the clinical diagnosis and treatment standards and the modernization of TCM.
