Meaning， Efficacy and Mechanism of Huoxin Pills in Treating Coronary Heart Disease with Qi Deficiency and Blood Stasis Syndrome
10.13422/j.cnki.syfjx.20220615
- VernacularTitle:活心丸防治气虚血瘀证冠心病分子机制及方义和疗效解析
- Author:
Xiu-juan YANG
1
;
Rui-xuan ZHU
1
;
Ran XIE
1
;
Lei YANG
2
;
Jin-cheng CHEN
2
;
Bao-xin XU
2
;
Xiao-chun SHI
2
;
Peng-qian WANG
1
;
Hai-ru HUO
1
;
Yu-qing TAN
1
;
Lyu GAO
1
;
Feng SUI
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. Youcare Pharmaceutical Group Co. Ltd.，Beijing 100176，China
- Publication Type:Review
- Keywords:
Huoxin pills;
coronary heart disease;
Qi deficiency and blood stasis syndrome;
molecular mechanism;
efficacy analysis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(9):205-213
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases， with high incidence and high mortality， belong to the category of "chest impediment and heart pain" in traditional Chinese medicine （TCM）. Chinese medicines have unique effect on the prevention and treatment of cardiovascular diseases with little side effects. Huoxin pills， one of the National Essential Drugs， is formulated based on the basic pathogenesis of weak pulse at Yang and wiry pulse at Yin and the pathological basis of myocardial ischemia and hypoxia and used for treating angina pectoris of coronary heart disease （Qi deficiency and blood stasis syndrome）. This medicine is derived from the classic famous prescription and is composed of ten precious Chinese medicinal herbs. It can replenish Qi， activate blood， and warm collaterals to diffuse impediment by enhancing myocardial contractility and cardiac output to improve micro-circulation and increase coronary blood flow， regulating immune functions， alleviating inflammation， detoxifying， and tranquilizing mind. Clinically， it is suitable for patients with angina pectoris caused by the lack of heart Yang， chest tightness， shortness of breath， palpitation， fear of cold for limbs and so on， especially for the elderly with Yang deficiency or the patients with a history of myocardial infarction. On the basis of the available research reports， this paper explains the formula meaning of Huoxin pills from the perspective of the basic pathogenesis of coronary heart disease and predicts its action targets， location and links. Furthermore， we expound the mechanism of action of Huoxin pills based on basic research and clinical evidence-based research， aiming to provide data support and evidence for the clinical application of this medicine.
