Mechanism of Cancer Drug Resistance and Reversal Effect of Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20212122
- VernacularTitle:肿瘤耐药性产生机制及中药逆转作用的研究进展
- Author:
Hui-ming HUANG
1
;
Ai-lin YANG
2
;
Ying-ying TIAN
1
;
Ya-xin LIU
1
;
Li-shan OUYANG
1
;
Peng-fei TU
1
;
Zhong-dong HU
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine，School of Chinese Materia Medica， Beijing University of Chinese Medicine，Beijing 100029，China
2. School of Pharmacy，Binzhou Medical University，Yantai 264003，China
- Publication Type:Journal Article
- Keywords:
cancer;
reverse drug resistance;
Chinese medicine;
mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(1):92-99
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is a serious threat to human life and health. The prevalence and mortality of malignancies in China are increasing year by year. Conquering cancer has become a difficult problem for human beings. Chemical drug therapy combined with molecular targeted therapy is a general and preferred anti-tumor clinical scheme， but the side effects and the drug resistance of cancer cells often hinder the efficacy. Therefore， it is of great significance to study the mechanism of drug resistance and the methods to reverse drug resistance. Chinese medicine has the characteristics of complex components， multiple targets， low toxicity， etc. A large number of experimental studies have demonstrated that the effective components or extracts of Chinese medicine can inhibit the proliferation， migration， and invasion of cancer cells， and induce apoptosis， autophagy， differentiation， and senescence. In clinical practice， Chinese medicine has been applied to the protection against ttumor， adjuvant treatment， and later consolidation. The research on Chinese medicine is expected to promote drug resistance reversal and cancer therapy. Studies have shown that the combination of Chinese medicine and chemotherapy can reverse drug resistance and increase efficacy， which has become the mainstream trend of cancer treatment. This study reviewed the mechanisms of the drug resistance of cancer cells induced by self-protective autophagy， gene mutation， high expression of enzymes， abnormal signaling pathways， and abnormal expression of RNA and protein， and summarized how compounds isolated from Chinese medicine， single drug and its extract， and classic anti-cancer prescription reversed the drug resistance to lay a solid foundation for the further investigation of the anti-tumor effect of Chinese medicine.
