Research Progress of Digestive System Disease and Syndrome Combined Animal Model and Traditional Chinese Medicine Target Intervention： A Review
10.13422/j.cnki.syfjx.20221845
- VernacularTitle:消化系统病证结合动物模型的研究进展及中医药靶点干预
- Author:
Wenjuan XU
1
;
Longde WANG
2
;
Yuanyuan NIU
1
;
Lanfang MAO
2
;
Xiaojuan DU
1
;
Ping ZHANG
1
Author Information
1. Gansu University of Traditional Chinese Medicine（TCM）， Lanzhou 730000， China
2. Affiliated Hospital of Gansu University of TCM， Lanzhou 730020， China
- Publication Type:Journal Article
- Keywords:
combination of disease and syndrome;
animal model;
reflux esophagitis;
nonalcoholic fatty liver disease;
functional dyspepsia
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(19):258-266
- CountryChina
- Language:Chinese
-
Abstract:
Reflux esophagitis （liver-stomach disharmony， Spittoon-Qi interties， Qi and blood stasis syndrome， turbid poison intrinsic） and nonalcoholic fatty liver disease （liver depression， spleen deficiency， phlegm and blood stasis syndrome， hot and humid embodiment， phlegmy wet resistance） and functional dyspepsia （liver depression syndrome， liver stomach with spleen deficient， spleen deficiency cold syndrome， in a word， fever） is a common disease and frequently encountered disease of digestive system. The course of disease is prolonged and the prevalence is high. The successful establishment of animal model combining disease and syndrome is the premise of exploring the mechanism of traditional Chinese medicine（TCM） effect and the foundation of the development of new preparations. At the same time， mastering the complex relationship network among disease， syndrome and prescription is the prerequisite of effective treatment. When the same syndrome occurs between different diseases， the concept of "treating different diseases with the same treatment" in TCM suggests that methods can be cross-referenced for the shortage of some syndrome models. TCM intervention of digestive diseases has the characteristics of multi-path， multi-target， multi-dimension and multi-level. Therefore， this article through the literature review， summarizes the reflux esophagitis， nonalcoholic fatty liver disease and functional dyspepsia is a common disease such as the combined operation method of the model and the intervention mechanism of TCM， so as to diseases of the digestive system of different syndrome types provides the theory basis for the objective of research， and the basic research of TCM prescription and achievements provide methodological guidance.
