Central nervous system infections caused by pathogenic free-living amoebae: An Indian perspective
https://doi.org/10.47665/tb.39.2.017
- Author:
Raju, R.
1
;
Khurana, S.
2
;
Mahadevan, A.
3
;
John, D.V.
4
Author Information
1. KIDWAI Memorial Institute of Oncology Research and Training Centre, Bangalore, India
2. Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
3. Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
4. Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India
- Publication Type:Journal Article
- Keywords:
CNS infections;
pathogenic free-living amoebae;
Acanthamoeba;
Balamuthia mandrillaris;
Naegleria fowleri.
- From:Tropical Biomedicine
2022;39(No.2):265-280
- CountryMalaysia
- Language:English
-
Abstract:
Pathogenic free-living amoebae (FLA), namely Acanthamoeba sp., Naegleria fowleri and Balamuthia
mandrillaris are distributed worldwide. These neurotropic amoebae can cause fatal central nervous
system (CNS) infections in humans. This review deals with the demographic characteristics, symptoms,
diagnosis, and treatment outcomes of patients with CNS infections caused by FLA documented in India.
There have been 42, 25, and 4 case reports of Acanthamoeba granulomatous amoebic encephalitis
(GAE), N. fowleri primary amoebic meningoencephalitis (PAM), and B. mandrillaris meningoencephalitis
(BAE), respectively. Overall, 17% of Acanthamoeba GAE patients and one of the four BAE patients
had some form of immunosuppression, and more than half of the N. fowleri PAM cases had history
of exposure to freshwater. Acanthamoeba GAE, PAM, and BAE were most commonly seen in males.
Fever, headache, vomiting, seizures, and altered sensorium appear to be common symptoms in these
patients. Some patients showed multiple lesions with edema, exudates or hydrocephalus in their brain
CT/MRI. The cerebrospinal fluid (CSF) of these patients showed elevated protein and WBC levels. Direct
microscopy of CSF was positive for amoebic trophozoites in 69% of Acanthamoeba GAE and 96% of
PAM patients. One-fourth of the Acanthamoeba GAE and all the BAE patients were diagnosed only
by histopathology following autopsy/biopsy samples. Twenty-one Acanthamoeba GAE survivors were
treated with cotrimoxazole, rifampicin, and ketoconazole/amphotericin B, and all eleven PAM survivors
were treated with amphotericin B alongside other drugs. A thorough search for these organisms in CNS
samples is necessary to develop optimum treatment strategies.
- Full text:8.2022my1342.pdf
