Susceptibility gene polymorphisms of primary knee osteoarthritis: a systematic review
10.3969/j.issn.1006-9771.2022.07.010
- VernacularTitle:原发性膝骨关节炎易感基因多态性位点的系统综述
- Author:
Shengfei LUO
1
;
Zhibo HU
2
;
Ninghua WANG
3
;
Hongwei MIN
4
;
Dejian ZHANG
4
;
Kemin LIU
4
Author Information
1. The Second Hospital of Tianjin Medical University, Tianjin 300211, China
2. Tianjin Medical University, Tianjin 300134, China
3. The First Hospital of Peking University, Beijing 100034, China
4. China Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
primary knee osteoarthritis;
genetic susceptibility;
single nucleotide polymorphism;
therapeutic targets;
systematic review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(7):803-808
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo conduct a systematic review of the susceptibility gene polymorphism sites of primary knee osteoarthritis (PKO). MethodsThe literature on genetic susceptibility and gene polymorphisms of PKO were retrieved from PubMed, Web of Science, CNKI, Wanfang Data, and China Biomedical Literature Database from establishment of the library to December, 2020, and systematically reviewed. ResultsA total of 42 papers on the polymorphism sites of human PKO susceptibility genes were included, involving cellular signaling pathways related to PKO pathogenesis, including inflammatory response, receptor signaling pathway, transcription factor signaling pathway, bone-related signaling pathway, etc. Multiple gene polymorphism sites located in inflammatory factor genes, chemokine genes, Toll-like receptor genes, transcription factor genes, obesity-related genes, and bone-related genes. ConclusionInflammatory factor genes and bone-associated allele polymorphisms are likely to be related to PKO susceptibility.
