Recent advances in research on chelators as metallo-β-lactamase inhibitors
10.11665/j.issn.1000-5048.20220404
- VernacularTitle:螯合剂类金属β-内酰胺酶抑制剂的研究进展
- Author:
Zhixi ZHU
1
;
Jielin ZHANG
;
Yijun CHEN
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
bacterial resistance;
metallo-β-lactamase;
inhibitor;
chelating agent;
advances
- From:
Journal of China Pharmaceutical University
2022;53(4):410-422
- CountryChina
- Language:Chinese
-
Abstract:
The major reason for the resistance of Gram-negative bacteria to β-lactam antibiotics is the expression of β-lactamases.Metallo-β-lactamases (MBL) hydrolyze almost all types of β-lactam antibiotics including carbapenems, posing a challenge to global public health. Developing MBL inhibitors is an important method to treat the infections caused by resistant bacteria. As an important type of MBL inhibitors, chelating agents can inhibit MBL by chelating, stripping, and binding Zn2+ in the active center of MBL.This review summarizes recent publications on chelators as MBL inhibitors, discussing their chemical structures, inhibitory potency, synergistic effects with antibiotics, selectivity and mechanism of action, including EDTA and related compounds, aspergillomarasmine A (AMA) and its derivatives, NOTA and related compounds, pyridine carboxylic acid and pyridine methylamine compounds, aiming to provide reference for future development of potent, selective and safe clinical MBL inhibitors.
