Application of nanomedicines targeting non-glucose nutrients in tumor starvation therapy
10.11665/j.issn.1000-5048.20220402
- VernacularTitle:靶向葡萄糖代谢以外营养物质的纳米药物在肿瘤饥饿治疗中的应用
- Author:
Zhiyan LI
1
;
Xianghui LI
;
Shichao AI
;
Yi YIN
;
Song LIU
;
Wenxian GUAN
Author Information
1. 南京大学医学院附属鼓楼医院胃肠外科
- Publication Type:Journal Article
- Keywords:
anomedicine;
starvation therapy;
cancer metabolism;
combined therapy
- From:
Journal of China Pharmaceutical University
2022;53(4):392-399
- CountryChina
- Language:Chinese
-
Abstract:
Starvation therapy is an emerging oncological treatment that targets the abnormally elevated nutrient uptake and metabolic pathways to inhibit and kill tumors. In addition to glucose, the targets of starvation therapy also include other nutrients in tumor cells.However, concerns like ineffective targeting and drug tolerance probably have an impact on their clinical translation.Nanomaterial-assisted starvation treatment has been developing quickly in recent years to address these concerns.In this review, several exemplary nanomedicines for starvation therapy and combined starvation therapy with other therapies were offered.They target nutrients other than glucose metabolism, including lactic acid, amino acids, and lipids, using nanomaterials to improve the efficacy of starvation therapy.This review provides reference for further development of nanomedicines with starvation treatment effect.
