Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma.
10.1016/j.apsb.2021.10.009
- Author:
Ying LIU
1
;
Yu HAN
2
;
Shizhu CHEN
3
;
Jingjie LIU
4
;
Dajiang WANG
4
;
Yifei HUANG
4
Author Information
1. Department of Ophthalmology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, China.
2. College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China.
3. China Resources Pharmaceutical Group Limited, Beijing 100000, China.
4. Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- Keywords:
ARVO, Association for Research in Vision and Ophthalmology;
DLS, dynamic light scattering;
DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine;
DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[(polyethylene glycol)-2000];
EE, encapsulation efficiency;
FL, fluorescence;
H&E, hematoxylin‒eosin;
ICG, indocyanine green;
ILP, ICG-loaded liposomes;
Imaging-guided;
LP, Liposomes;
Liposomes;
Nanoplatform;
PA, photoacoustic;
PBS, phosphate-buffered saline;
PDT, photodynamic therapy;
PDTX, patient-derived tumor xenograft;
PTT, photothermal therapy;
Photothermal therapy;
Rb, retinoblastoma;
Retinoblastoma;
TEM, transmission electron microscopy
- From:
Acta Pharmaceutica Sinica B
2022;12(6):2731-2739
- CountryChina
- Language:English
-
Abstract:
Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG in vivo, but also realized imaging-guide photothermal therapy, which created a new strategy for the treatment of retinoblastoma.
