Mitochondria targeting drugs for neurodegenerative diseases-Design, mechanism and application.
10.1016/j.apsb.2022.03.001
- Author:
Jiajia XU
1
;
Wei DU
1
;
Yunhe ZHAO
2
;
Kahleong LIM
3
;
Li LU
2
;
Chengwu ZHANG
1
;
Lin LI
1
Author Information
1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China.
2. Department of Anatomy, Shanxi Medical University, Taiyuan 030001, China.
3. Lee Kang Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
- Publication Type:Review
- Keywords:
Adenosine triphosphate;
Apoptosis;
Evaluation;
Mitochondria;
Mitochondrial membrane potential;
Neurodegenerative diseases;
Reactive oxygen species;
Targeting drug
- From:
Acta Pharmaceutica Sinica B
2022;12(6):2778-2789
- CountryChina
- Language:English
-
Abstract:
Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs. Dysfunction of mitochondria results in energy depletion, oxidative stress, calcium overloading, caspases activation, which dominates the neuronal death of NDDs. Therefore, mitochondria are the preferred target for intervention of NDDs. So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome, though there are still some obstacles such as targeting specificity, delivery capacity hindering the drugs development. In present review, we will elaborately address 1) the strategy to design mitochondria targeting drugs, 2) the rescue mechanism of respective mitochondria targeting drugs, 3) how to evaluate the therapeutic effect. Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs.
