Chemotherapeutic nanomaterials in tumor boundary delineation: Prospects for effective tumor treatment.
10.1016/j.apsb.2022.02.016
- Author:
Ozioma Udochukwu AKAKURU
1
;
Zhoujing ZHANG
2
;
M Zubair IQBAL
1
;
Chengjie ZHU
1
;
Yewei ZHANG
2
;
Aiguo WU
1
Author Information
1. Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, China.
2. School of Medicine, Southeast University, Nanjing 210009, China.
- Publication Type:Review
- Keywords:
Bioimaging;
Boundary delineation;
Surgery;
Tumor;
Tumor imaging;
Tumor therapy
- From:
Acta Pharmaceutica Sinica B
2022;12(6):2640-2657
- CountryChina
- Language:English
-
Abstract:
Accurately delineating tumor boundaries is key to predicting survival rates of cancer patients and assessing response of tumor microenvironment to various therapeutic techniques such as chemotherapy and radiotherapy. This review discusses various strategies that have been deployed to accurately delineate tumor boundaries with particular emphasis on the potential of chemotherapeutic nanomaterials in tumor boundary delineation. It also compiles the types of tumors that have been successfully delineated by currently available strategies. Finally, the challenges that still abound in accurate tumor boundary delineation are presented alongside possible perspective strategies to either ameliorate or solve the problems. It is expected that the information communicated herein will form the first compendious baseline information on tumor boundary delineation with chemotherapeutic nanomaterials and provide useful insights into future possible paths to advancing current available tumor boundary delineation approaches to achieve efficacious tumor therapy.
