Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction.
10.1016/j.apsb.2022.01.013
- Author:
Shanmin ZHENG
1
;
Jiawei GUO
2
;
Fangyuan CHENG
2
;
Zhengquan GAO
3
;
Lei DU
2
;
Chunxiao MENG
1
;
Shengying LI
2
;
Xingwang ZHANG
2
Author Information
1. School of Life Sciences, Shandong University of Technology, Zibo 255000, China.
2. State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
3. School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
- Publication Type:Review
- Keywords:
Algae;
Algal pharmaceuticals;
Cytochrome P450 enzymes;
Light-driven bioproduction;
Natural product biosynthesis
- From:
Acta Pharmaceutica Sinica B
2022;12(6):2832-2844
- CountryChina
- Language:English
-
Abstract:
Algae are a large group of photosynthetic organisms responsible for approximately half of the earth's total photosynthesis. In addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life, algae are also a rich source of bioactive natural products, including several clinical drugs. Cytochrome P450 enzymes (P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of reactions. In the post-genome era, a growing number of P450 genes have been discovered from algae, indicating their important roles in algal life-cycle. However, the functional studies of algal P450s remain limited. Benefitting from the recent technical advances in algae cultivation and genetic manipulation, the researches on P450s in algal natural product biosynthesis have been approaching to a new stage. Moreover, some photoautotrophic algae have been developed into "photo-bioreactors" for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative manner. Here, we comprehensively review these advances of P450 studies in algae from 2000 to 2021.
