Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza).
10.1016/S1875-5364(22)60165-1
- Author:
Wei GAO
1
;
Yi WANG
1
;
Ru WANG
1
;
Yi-Hai WANG
2
,
3
;
Jing-Wen XU
2
,
4
;
Xiang-Jiu HE
2
,
5
Author Information
1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
2. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
3. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address: wangyih88@163.com.
4. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China.
5. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address: hexiangjiu@163.com.
- Publication Type:Journal Article
- Keywords:
Alocasia macrorrhiza;
Antiproliferative;
Apoptosis;
Giant taro;
Piperidine alkaloids
- MeSH:
Alkaloids/pharmacology*;
Alocasia/chemistry*;
Humans;
Piperidines/pharmacology*;
Plants;
Rhizome/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(7):541-550
- CountryChina
- Language:English
-
Abstract:
The rhizome of giant taro (Alocasia macrorrhiza (L.) Schott), which is a highly adaptable wild plant, is a traditional Chinese herbal medicine. In the current study, the antiproliferative constituents of giant taro were investigated and six new (1-6) and four known piperidine alkaloids (7-10) were isolated from its rhizomes. Their chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester method. The isolated alkaloids were screened for the antiproliferative activity through MTT assay. The results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2, AGS and MCF-7 tumor cells. Further researches showed that compounds 3-5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells, while compound 4 induced AGS cell death via the proapoptotic pathway. This study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity, which provides phytochemical evidence for further development and utilization.
