Ascyrones A-E, type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron.
10.1016/S1875-5364(22)60167-5
- Author:
Xin DENG
1
,
2
;
Jing XIA
1
,
2
;
Meng-Yu QIAN
1
,
2
;
Xiu-Rong WANG
1
,
2
;
Bo HU
1
,
2
;
Xue-Song LIU
1
,
3
;
Lin WU
1
,
4
Author Information
1. School of Pharmacy, Anhui Medical University
2. Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China.
3. Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China. Electronic address: chemxsliu@126.com.
4. Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China. Electronic address: wulin@ahmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acylphloroglucinol;
Anti-inflammatory activity;
Hypericum ascyron;
Neuroprotective activity
- MeSH:
Animals;
Anti-Inflammatory Agents/pharmacology*;
Hypericum/chemistry*;
Molecular Structure;
PC12 Cells;
Phloroglucinol/pharmacology*;
Rats
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(6):473-480
- CountryChina
- Language:English
-
Abstract:
Five new polycyclic polyprenylated acylphloroglucinols (1-5), ascyrones A-E, and four known compounds (6-9) were isolated from the aerial parts of Hypericum ascyron. All of the isolates containing a bicyclo[3.3.1]nonane-2,4,9-trione core and a benzoyl group, belonged to type B bicyclic polyprenylated acylphloroglucinols (BPAPs). Their structures and absolute configurations were established based on spectroscopic analyses and calculated electronic circular dichroism (ECD) data. The anti-inflammatory, neuroprotective and cytotoxicity activities of compounds 1-4 and 6-9 were evaluated. Compound 6 exhibited obvious anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 cells. Compounds 1 and 9 exhibited slight cytotoxicity against Hep3B cells. Meanwhile, compound 1 showed mild neuroprotective activity against corticosterone (CORT)-induced PC12 cell damage at 10 μmol·L-1.
