Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells.

Hezhen Shan; Lingling Geng; Xiaoyu Jiang; Moshi Song; Jianxun Wang; Zunpeng Liu; Xiao Zhuo; Zeming WU; Jianli HU; Zhejun JI; Si Wang; Piu Chan; Jing QU; Weiqi Zhang; Guang-hui Liu

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Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells.

Author: Hezhen SHAN ¹ ; Lingling GENG ² ; Xiaoyu JIANG ¹ ; Moshi SONG ¹ ; Jianxun WANG ³ ; Zunpeng LIU ⁴ ; Xiao ZHUO ⁵ ; Zeming WU ¹ ; Jianli HU ⁵ ; Zhejun JI ⁴ ; Si WANG ² ; Piu CHAN ² ; Jing QU ⁶ ; Weiqi ZHANG ⁷ ; Guang-Hui LIU ⁸
Author Information

1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
2. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
3. School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
4. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
5. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
6. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
7. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
8. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
Publication Type:Research Support, Non-U.S. Gov't
MeSH: Gallic Acid/pharmacology*; Humans; Senotherapeutics; Stem Cells
From: Protein & Cell 2022;13(7):532-539
CountryChina
Language:English