A hierarchical vascularized engineered bone inspired by intramembranous ossification for mandibular regeneration.
10.1038/s41368-022-00179-z
- Author:
Xin YE
1
;
Jianxiang HE
1
;
Shaolong WANG
1
;
Qianglong HAN
2
;
Dongqi YOU
1
;
Bin FENG
1
;
Feiya ZHAO
1
;
Jun YIN
3
;
Mengfei YU
4
;
Huiming WANG
1
;
Huayong YANG
2
Author Information
1. Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China.
2. The State Key Laboratory of Fluid Power and Mechatronic Systems, Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
3. The State Key Laboratory of Fluid Power and Mechatronic Systems, Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, China. junyin@zju.edu.cn.
4. Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Hangzhou, China. yumengfei@zju.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Bone Regeneration;
Bone Transplantation/methods*;
Hedgehog Proteins;
Humans;
Mandible/surgery*;
Osteogenesis
- From:
International Journal of Oral Science
2022;14(1):31-31
- CountryChina
- Language:English
-
Abstract:
Mandibular defects caused by injuries, tumors, and infections are common and can severely affect mandibular function and the patient's appearance. However, mandible reconstruction with a mandibular bionic structure remains challenging. Inspired by the process of intramembranous ossification in mandibular development, a hierarchical vascularized engineered bone consisting of angiogenesis and osteogenesis modules has been produced. Moreover, the hierarchical vascular network and bone structure generated by these hierarchical vascularized engineered bone modules match the particular anatomical structure of the mandible. The ultra-tough polyion complex has been used as the basic scaffold for hierarchical vascularized engineered bone for ensuring better reconstruction of mandible function. According to the results of in vivo experiments, the bone regenerated using hierarchical vascularized engineered bone is similar to the natural mandibular bone in terms of morphology and genomics. The sonic hedgehog signaling pathway is specifically activated in hierarchical vascularized engineered bone, indicating that the new bone in hierarchical vascularized engineered bone underwent a process of intramembranous ossification identical to that of mandible development. Thus, hierarchical vascularized engineered bone has a high potential for clinical application in mandibular defect reconstruction. Moreover, the concept based on developmental processes and bionic structures provides an effective strategy for tissue regeneration.
