Estrogen Receptor-A in Medial Preoptic Area Contributes to Sex Difference of Mice in Response to Sevoflurane Anesthesia.
10.1007/s12264-022-00825-w
- Author:
Yunyun ZHANG
1
;
Huiming LI
1
;
Xinxin ZHANG
1
;
Sa WANG
1
;
Dan WANG
1
;
Jiajia WANG
1
;
Tingting TONG
1
;
Zhen ZHANG
1
;
Qianzi YANG
2
;
Hailong DONG
3
Author Information
1. Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
2. Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China. qianziyang@hotmail.com.
3. Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China. hldong6@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Anesthesia;
Estrogen receptor alpha;
Medial preoptic area;
Sevoflurane;
Sex difference
- MeSH:
Anesthesia;
Animals;
Estrogen Receptor alpha/metabolism*;
Female;
Male;
Mice;
Preoptic Area;
Sevoflurane/pharmacology*;
Sex Characteristics
- From:
Neuroscience Bulletin
2022;38(7):703-719
- CountryChina
- Language:English
-
Abstract:
A growing number of studies have identified sex differences in response to general anesthesia; however, the underlying neural mechanisms are unclear. The medial preoptic area (MPA), an important sexually dimorphic structure and a critical hub for regulating consciousness transition, is enriched with estrogen receptor alpha (ERα), particularly in neuronal clusters that participate in regulating sleep. We found that male mice were more sensitive to sevoflurane. Pharmacological inhibition of ERα in the MPA abolished the sex differences in sevoflurane anesthesia, in particular by extending the induction time and facilitating emergence in males but not in females. Suppression of ERα in vitro inhibited GABAergic and glutamatergic neurons of the MPA in males but not in females. Furthermore, ERα knockdown in GABAergic neurons of the male MPA was sufficient to eliminate sex differences during sevoflurane anesthesia. Collectively, MPA ERα positively regulates the activity of MPA GABAergic neurons in males but not in females, which contributes to the sex difference of mice in sevoflurane anesthesia.
