Formation of the Looming-evoked Innate Defensive Response during Postnatal Development in Mice.
10.1007/s12264-022-00821-0
- Author:
Shanping CHEN
1
;
Huiying TAN
1
;
Zhijie WANG
1
;
Yu-Ting TSENG
1
;
Xiaotao LI
1
;
Liping WANG
2
Author Information
1. Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-ShenzhenFundamental Research Institutions, Shenzhen, 518055, China.
2. Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-ShenzhenFundamental Research Institutions, Shenzhen, 518055, China. lp.wang@siat.ac.cn.
- Publication Type:Journal Article
- Keywords:
Innate defensive response;
Postnatal stage;
Superior colliculus
- MeSH:
Animals;
Evoked Potentials, Visual;
Fear/physiology*;
Mammals;
Mice;
Mice, Inbred C57BL;
Neurons/physiology*;
Superior Colliculi/physiology*
- From:
Neuroscience Bulletin
2022;38(7):741-752
- CountryChina
- Language:English
-
Abstract:
Environmental threats often trigger innate defensive responses in mammals. However, the gradual development of functional properties of these responses during the postnatal development stage remains unclear. Here, we report that looming stimulation in mice evoked flight behavior commencing at P14-16 and had fully developed by P20-24. The visual-evoked innate defensive response was not significantly altered by sensory deprivation at an early postnatal stage. Furthermore, the percentages of wide-field and horizontal cells in the superior colliculus were notably elevated at P20-24. Our findings define a developmental time window for the formation of the visual innate defense response during the early postnatal period and provide important insight into the underlying mechanism.
