ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA <i>CYTOR</i> and influences pharmacotherapy response in colon adenocarcinoma.

Lu Xia; Hexin Lin; Yanming Zhou; Jiabian Lian

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ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma.

Author: Lu XIA ¹ ; Hexin LIN ² ; Yanming ZHOU ³ ; Jiabian LIAN ⁴
Author Information

1. Xiamen Cell Therapy Research Center, the First Affiliated Hospital of Xiamen University, Xiamen 361000, China.
2. Department of Colorectal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China.
3. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Xiamen University, Xiamen 361000, China.
4. Department of Clinical Laboratory, the First Affiliated Hospital of Xiamen University, Xiamen 361000, China. faster_lian@xmu.edu.cn.
Publication Type:Journal Article
MeSH: Adenocarcinoma/metabolism*; Carcinogenesis/genetics*; Colonic Neoplasms/metabolism*; Histone Demethylases/metabolism*; Humans; RNA, Long Noncoding/genetics*; Transcription Factors/metabolism*; Tumor Suppressor Proteins/metabolism*
From: Journal of Zhejiang University. Science. B 2022;23(7):587-596
CountryChina
Language:English
Abstract: The epidermal cell differentiation regulator zinc finger protein 750 (ZNF750) is a transcription factor containing the Cys2His2 (C2H2) domain, the zinc finger structure of which is located at the N-terminal 25‍‍-‍46 amino acids of ZNF750. It can promote the expression of differentiation-related factors while inhibiting the expression of progenitor cell-related genes. ZNF750 is directly regulated by p63 (encoded by the TP63 gene, belonging to the TP53 superfamily). The Krüppel-like factor 4 (KLF4), repressor element-1 (RE-1)‍-silencing transcription factor (REST) corepressor 1 (RCOR1), lysine demethylase 1A (KDM1A), and C-terminal-binding protein 1/2 (CTBP1/2) chromatin regulators cooperate with ZNF750 to repress epidermal progenitor genes and activate the expression of epidermal terminal differentiation genes (Sen et al., 2012; Boxer et al., 2014). Besides, ZNF750 and the regulatory network composed of bone morphogenetic protein (BMP) signaling pathway, long non-coding RNAs (lncRNAs) (anti-differentiation non-coding RNA (ANCR) and tissue differentiation-inducing non-protein coding RNA (TINCR)), musculoaponeurotic fibrosarcoma oncogene (MAF)/MAF family B (MAFB), grainy head-like 3 (GRHL3), and positive regulatory domain zinc finger protein 1 (PRDM1) jointly promote epidermal cell differentiation (Sen et al., 2012).