Co-regulation of circadian clock genes and microRNAs in bone metabolism.

Tingting LI; Shihua Zhang; Yuxuan Yang; Lingli Zhang; Yu Yuan; Jun Zou

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Co-regulation of circadian clock genes and microRNAs in bone metabolism.

Author: Tingting LI ¹ ; Shihua ZHANG ² ; Yuxuan YANG ³ ; Lingli ZHANG ³ ; Yu YUAN ⁴ ; Jun ZOU ⁵
Author Information

1. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China.
2. College of Graduate Education, Jinan Sport University, Jinan 250102, China.
3. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
4. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China. junzou@sus.edu.cn, yuanyumail@126.com.
5. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China. junzou@sus.edu.cn.
Publication Type:Review
Keywords: Bone metabolism; Circadian clock gene; Circadian rhythm; MicroRNAs
MeSH: Animals; Circadian Clocks/genetics*; Circadian Rhythm/genetics*; Mammals/genetics*; MicroRNAs/genetics*; Osteogenesis/genetics*; Osteoporosis/genetics*
From: Journal of Zhejiang University. Science. B 2022;23(7):529-546
CountryChina
Language:English
Abstract: Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation, mediated by osteoclasts and osteoblasts. It is widely recognized that circadian clock genes can regulate bone metabolism. In recent years, the regulation of bone metabolism by non-coding RNAs has become a hotspot of research. MicroRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism, including circadian clock genes. However, research in this field has been conducted only in recent years and the mechanisms involved are not yet well established. Recent studies have focused on how to target circadian clock genes to treat some diseases, such as autoimmune diseases, but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases. Therefore, in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.