Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis.

Author: Jiaqi LU ¹ ; Jingyuan LIU ¹ ; Ang LI ²
Author Information

1. Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
2. Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. liang@ccmu.edu.cn.
Publication Type:Review
Keywords: Neutrophils; Organ dysfunction; Oxidative stress; Reactive oxygen species (ROS); Sepsis
MeSH: Critical Illness; Humans; Neutrophils; Reactive Oxygen Species; Sepsis/complications*; Shock, Septic
From: Journal of Zhejiang University. Science. B 2022;23(6):437-450
CountryChina
Language:English
Abstract: Sepsis is a condition of severe organ failure caused by the maladaptive response of the host to an infection. It is a severe complication affecting critically ill patients, which can progress to severe sepsis, septic shock, and ultimately death. As a vital part of the human innate immune system, neutrophils are essential in resisting pathogen invasion, infection, and immune surveillance. Neutrophil-produced reactive oxygen species (ROS) play a pivotal role in organ dysfunction related to sepsis. In recent years, ROS have received a lot of attention as a major cause of sepsis, which can progress to severe sepsis and septic shock. This paper reviews the existing knowledge on the production mechanism of neutrophil ROS in human organ function impairment because of sepsis.