Vitamin D/vitamin D receptor, autophagy, and infection.
10.11817/j.issn.1672-7347.2022.210556
- Author:
Yu HOU
1
;
Jinghui LI
2
;
Chao DENG
3
Author Information
1. Department of Critical Care Medicine, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China. stella314@163.com.
2. Department of Critical Care Medicine, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China. shuo7076@163.com.
3. Department of Critical Care Medicine, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China.
- Publication Type:Journal Article
- Keywords:
autophagy;
infection;
vitamin D;
vitamin D receptor
- MeSH:
Animals;
Autophagy;
Humans;
Inflammation;
Mammals/metabolism*;
Receptors, Calcitriol/metabolism*;
Vitamin D/physiology*;
Vitamins
- From:
Journal of Central South University(Medical Sciences)
2022;47(6):780-785
- CountryChina
- Language:English
-
Abstract:
Vitamin D plays an important role in mineral and bone homeostasis, immune responses, cardiovascular function and keratinocyte proliferation and differentiation. Vitamin D performs most of its functions by binding to vitamin D receptors (VDR), which interact with other intracellular signaling pathways to regulate bone metabolism, inflammation, immunity, cell cycle progression and apoptosis. Autophagy is a basic stress response in yeast, plants and mammals, and plays a critical role in maintaining optimal functional states at the level of cells and organs. Vitamin D/VDR plays an anti-infection role via inducing and regulating autophagy.
