Intra-Articular Pigmentation of Synovium: An Unusual Cause.
10.4055/cios.2016.8.3.330
- Author:
Shobhit VERMA
1
;
Steven HAMILTON
;
Sue M LIEW
Author Information
1. Department of Trauma and Orthopaedics, The Alfred, Melbourne, Australia. drasverma@yahoo.co.in
- Publication Type:Case Reports
- Keywords:
Knee;
Arthroscopy;
Synovium;
Pigmentation;
Articular
- MeSH:
Aged;
Amiodarone/*adverse effects/therapeutic use;
Anti-Arrhythmia Agents/*adverse effects/therapeutic use;
Arrhythmias, Cardiac/complications/drug therapy;
Arthroscopy;
Diagnosis, Differential;
Humans;
Knee Joint/surgery;
Male;
Pigmentation Disorders/*chemically induced/*diagnosis;
Skin/pathology;
Synovial Membrane/*pathology
- From:Clinics in Orthopedic Surgery
2016;8(3):330-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
An unusual grayish brown discoloration of the synovium was found during a knee arthroscopy of a 72-year-old man. He also had similar pigmentation affecting the skin on the legs, arms, hands, and face. It was found he had been taking 400 mg of amiodarone hydrochloride daily for last 7 years. Amiodarone is known to cause a slate grey pigmentation of skin and cornea, but we believe this is the first report of amiodarone-induced pigmentation of the synovium. The arthroscopist should be aware of the possibility of drug-related synovial pigmentation and include this in differential diagnosis.
