Research Progress on Immunomodulatory Activity and Clinical Application of Mesenchymal Stem Cells-Derived Extracellular Vesicles--Review.
10.19746/j.cnki.issn.1009-2137.2022.03.047
- Author:
Jie ZHAO
1
;
Yan JIANG
1
;
Si-Guo HAO
2
Author Information
1. Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
2. Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China,E-mail: haosiguo@xinhuamed.com.
- Publication Type:Review
- Keywords:
extracellular vesicle;
hematopoietic stem cell transplantation;
immune modulation;
mesenchymal stem cell
- MeSH:
Cell Differentiation;
Extracellular Vesicles/transplantation*;
Graft vs Host Disease/metabolism*;
Hematopoietic Stem Cell Transplantation;
Humans;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells
- From:
Journal of Experimental Hematology
2022;30(3):955-958
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSC) have been widely used in tissue regeneration and treatment graft versus host disease (GVHD) and immune diseases due to their self-renewal, multi-differentiation and immunoregulatory potential. However, more and more scholars begin to put weight on the MSC -derived extracellular vesicles (MSC-EV) for its regulation of inflammation and immunity. MSC-EV can activate the relevant signal pathways and regulate the function and biological behaviors of cells via acting on target cells and mediating communication between cells. MSC-EV has important potential clinical applications for its powerful immunomodulatory and hematopoietic regulatory functions. It is considered as a potential therapeutic tool to treat autoimmune diseases and GVHD. This paper reviewed the immunomodulatory activity of MSC-EV as well as the research progress of MSC-EV in hematopoietic stem cell transplantation, and discussed its potential clinical applications in the future.
