Correlation between Serum G-CSF Level and Immune Function in Children with Aplastic Anemia.
10.19746/j.cnki.issn.1009-2137.2022.03.025
- Author:
Rong REN
1
;
Jing HAN
2
Author Information
1. Department of Pediatric Hematology, Tangshan Maternal & Child Health Hospital, Tangshan 063000, Hebei Province, China,E-mail: eavorforever@163.com.
2. Department of Pediatric Hematology, Tangshan Maternal & Child Health Hospital, Tangshan 063000, Hebei Province, China.
- Publication Type:Journal Article
- Keywords:
aplastic anemia;
granulocyte colony stimulating factor;
immune dysfunction;
immunosuppressive therapy
- MeSH:
Anemia, Aplastic;
Antilymphocyte Serum/therapeutic use*;
Child;
Cyclosporine/therapeutic use*;
Granulocyte Colony-Stimulating Factor;
Humans;
Immunity;
Immunosuppressive Agents/therapeutic use*
- From:
Journal of Experimental Hematology
2022;30(3):819-823
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the occurrence of immune dysfunction in children with aplastic anemia (AA) and the factors that may lead to immune dysfunction, analyze the relationship between the expression of granulocyte colony stimulating factor (G-CSF) and immune dysfunction.
METHODS:A total of 34 children with AA treated in our hospital from December 2016 to September 2018 were selected. All the children received immunosuppressive therapy (IST) for 6 months. According to whether the children had immune dysfunction after 6 months of treatment, they were divided into occurrence group and non occurrence group. General information and laboratory indices were compared between the two groups, and serum G-CSF level was tested, the relationship between serum G-CSF level and immune dysfunction in AA children after treatment with IST was observed and analyzed.
RESULTS:After treatment with IST for 6 months, 12 cases developed immune dysfunction (35.29%). Serum interferon (IFN)-γ level of the occurrence group was higher but G-CSF level was lower than those of the non occurrence group (P<0.05), while the difference of other baseline data was not statistically significant (P>0.05). Multiple regression analysis showed that overexpression of serum IFN-γ and low expression of G-CSF were both the influencing factors of immune dysfunction in AA children after IST treatment (OR>1, P<0.05). ROC curve was drawn, and the result showed that the area under the curve (AUC) of serum G-CSF level predicted the risk of immune dysfunction after IST was 0.843>0.80, when the index cut-off value was set at 6.614 pg/ml, the predictive value was ideal.
CONCLUSION:AA children have a higher risk of immune dysfunction after IST, which may be related to the low expression of serum G-CSF. The detection of serum G-CSF expression can be considered to predict the risk of immune dysfunction in AA children after IST, so as to guide early clinical intervention.
