Recurrent epistaxis with coagulation disorders in a boy aged 2 years.
10.7499/j.issn.1008-8830.2203060
- Author:
Jia-Zhuo LI
1
;
Xin TIAN
1
;
Chu-Shu LIAO
;
Xiang-Ling HE
1
;
Cheng-Guang ZHU
1
Author Information
1. Department of Hematology and Oncology, First Affiliated Hospital of Hunan Normal University/Children's Medical Center, Hunan Provincial People's Hospital, Changsha 410005, China.
- Publication Type:Journal Article
- Keywords:
Child;
Coagulation function;
Epistaxis;
Hypoprothrombinemia-lupus anticoagulant syndrome
- MeSH:
Antiphospholipid Syndrome/diagnosis*;
Blood Coagulation Disorders;
Child, Preschool;
Epistaxis/etiology*;
Humans;
Hypoprothrombinemias/diagnosis*;
Lupus Coagulation Inhibitor;
Male;
Partial Thromboplastin Time;
Prothrombin
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(7):817-820
- CountryChina
- Language:Chinese
-
Abstract:
A boy, aged 2 years and 5 months, had recurrent epistaxis, and the coagulation function examination showed that activated partial thromboplastin time (APTT) was significantly prolonged. Further laboratory examinations showed that the prolonged APTT was not immediately corrected in the APTT correction test, with positive lupus anticoagulant and low prothrombin activity. The boy was diagnosed with hypoprothrombinemia-lupus anticoagulant syndrome. The condition was improved after treatment with glucocorticoid, immunoglobulin, and vitamin K1. The boy has been followed up for 6 months, and no epistaxis was observed. Prothrombin activity returned to normal, and lupus anticoagulant remained positive. This is a relatively rare disease, and for patients with bleeding symptoms and coagulation disorders, it is recommended to perform the tests such as APTT correction test, lupus anticoagulant testing, and coagulation factor dilution test, which can improve the detection rate of this disease, so as to achieve early diagnosis, provide rational treatment in the early stage, and improve the prognosis.
