Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases.
10.7499/j.issn.1008-8830.2204074
- Author:
Ping-Ping ZHANG
1
;
Yan-Ting GUO
1
;
Yu-Qin CHU
1
;
Q I JI
1
;
Yan LIAN
1
;
Wei LI
1
;
Li-Na YAO
1
Author Information
1. Department of Pediatrics, Tianjin First Central Hospital, Tianjin 300190, China.
- Publication Type:Journal Article
- Keywords:
Child;
Coronavirus disease 2019;
IgG;
Omicron;
Recovery stage;
Vaccination
- MeSH:
Antibodies, Viral;
COVID-19;
COVID-19 Vaccines;
Child;
Humans;
Immunoglobulin G;
Retrospective Studies;
SARS-CoV-2;
Viral Vaccines
- From:
Chinese Journal of Contemporary Pediatrics
2022;24(7):736-741
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To investigate the serum level of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific RBD IgG antibody (SARS-CoV-2 IgG antibody for short) in children with SARS-CoV-2 Omicron variant infection during the recovery stage, as well as the protective effect of SARS-CoV-2 vaccination against Omicron infection.
METHODS:A retrospective analysis was performed on 110 children who were diagnosed with coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 Omicron variant infection in Tianjin of China from January 8 to February 7, 2022. According to the status of vaccination before diagnosis, they were divided into a booster vaccination (3 doses) group with 2 children, a complete vaccination (2 doses) group with 90 children, an incomplete vaccination (1 dose) group with 5 children, and a non-vaccination group with 13 children. The clinical data and IgG level were compared among the 4 groups.
RESULTS:The complete vaccination group had a significantly higher age than the non-vaccination group at diagnosis (P<0.05), and there was a significant difference in the route of transmission between the two groups (P<0.05). There were no significant differences among the four groups in sex, clinical classification, and re-positive rate of SARS-CoV-2 nucleic acid detection (P>0.05). All 97 children were vaccinated with inactivated vaccine, among whom 85 children (88%) were vaccinated with BBIBP-CorV Sinopharm vaccine (Beijing Institute of Biological Products, Beijing, China). At 1 month after diagnosis, the booster vaccination group and the complete vaccination group had a significantly higher level of SARS-CoV-2 IgG antibody than the non-vaccination group (P<0.05), and at 2 months after diagnosis, the complete vaccination group had a significantly higher level of SARS-CoV-2 IgG antibody than the non-vaccination group (P<0.05). For the complete vaccination group, the level of SARS-CoV-2 IgG antibody at 2 months after diagnosis was significantly lower than that at 1 month after diagnosis (P<0.05).
CONCLUSIONS:Vaccination with inactivated SARS-CoV-2 vaccine has a protective effect against Omicron infection in children. For children vaccinated with 2 doses of the vaccine who experience Omicron infection, there may be a slight reduction in the level of SARS-CoV-2 IgG antibody at 2 months after diagnosis. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(7): 736-741.
