The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study.
- Author:
Yong Peng ZHANG
1
;
Ya Xing WANG
2
;
Jin Qiong ZHOU
1
;
Qian WANG
1
;
Yan Ni YAN
1
;
Xuan YANG
1
;
Jing Yan YANG
1
;
Wen Jia ZHOU
1
;
Ping WANG
1
;
Chang SHEN
1
;
Ming YANG
1
;
Ya Nan LUAN
1
;
Jin Yuan WANG
1
;
Shou Ling WU
3
;
Shuo Hua CHEN
4
;
Hai Wei WANG
5
;
Li Jian FANG
6
;
Qian Qian WAN
7
;
Jing Yuan ZHU
1
;
Zi Han NIE
1
;
Yu Ning CHEN
1
;
Ying XIE
8
;
J B JONAS
9
;
Wen Bin WEI
1
Author Information
- Publication Type:Journal Article
- Keywords: Age-related macular degeneration; Diabetes; Hyperlipidemia; Hypertension; Prevalence; Risk factor
- MeSH: Cross-Sectional Studies; Diabetes Mellitus/epidemiology*; Humans; Hyperlipidemias/epidemiology*; Hypertension/epidemiology*; Macular Degeneration/etiology*; Risk Factors
- From: Biomedical and Environmental Sciences 2022;35(7):613-621
- CountryChina
- Language:English
-
Abstract:
Objective:To analyze the prevalence of dry and wet age-related macular degeneration (AMD) in patients with diabetes, hypertension and hyperlipidemia, and to analyze the risk factors for AMD.
Methods:A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals. We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.
Results:The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3% and 0.5%, respectively, and the prevalence of dry AMD was 17% and 16.4%, respectively. The prevalence of wet AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 0.5%, 0.3%, 0.2%, and 0.7%, respectively. The prevalence of dry AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 16.6%, 16.2%, 15.2%, and 17.2%, respectively. Age, sex, body mass index, and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD. Diabetes, diabetes/hypertension, diabetes/hyperlipidemia, and diabetes/hypertension/hyperlipidemia were analyzed. None of the factors analyzed in the current study increased the risk for the onset of AMD.
Conclusion:There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects. Similarly, there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia. Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD.