MicroRNA-125b Accelerates and Promotes PML-RARa-driven Murine Acute Promyelocytic Leukemia.
- Author:
Bo GUO
1
,
2
,
3
;
Ran QIN
4
;
Ji Jun CHEN
2
,
3
;
Wen PAN
2
,
3
;
Xue Chun LU
4
Author Information
- Publication Type:Journal Article
- Keywords: Bone marrow blast; PML-RARA; White blood cell; miR-125b
- MeSH: Animals; Humans; Leukemia, Promyelocytic, Acute/metabolism*; Mice; MicroRNAs/genetics*; Oncogene Proteins, Fusion/therapeutic use*
- From: Biomedical and Environmental Sciences 2022;35(6):485-493
- CountryChina
- Language:English
-
Abstract:
Objective:Most acute promyelocytic leukemia cases are characterized by the PML-RARa fusion oncogene and low white cell counts in peripheral blood.
Methods:Based on the frequent overexpression of miR-125-family miRNAs in acute promyelocytic leukemia, we examined the consequence of this phenomenon by using an inducible mouse model overexpressing human miR-125b.
Results:MiR-125b expression significantly accelerates PML-RARa-induced leukemogenesis, with the resultant induced leukemia being partially dependent on continued miR-125b overexpression. Interestingly, miR-125b expression led to low peripheral white cell counts to bone marrow blast percentage ratio, confirming the clinical observation in acute promyelocytic leukemia patients.
Conclusion:This study suggests that dysregulated miR-125b expression is actively involved in disease progression and pathophysiology of acute promyelocytic leukemia, indicating that targeting miR-125b may represent a new therapeutic option for acute promyelocytic leukemia.
