The role and molecular mechanism of miR-494 in disease development and progression.
- Author:
Xia MO
1
;
Ning CHEN
1
;
Jin-Xiu LI
1
;
Yan-Ju GUO
2
;
Jing-Jing FAN
1
Author Information
1. College of Health Science, Wuhan Sports University, Wuhan 430079, China.
2. College of Physical Education and Health, Guangxi Normal University, Guilin 541004, China. guoyj_2520@163.com.
- Publication Type:Journal Article
- MeSH:
MicroRNAs/metabolism*;
NF-kappa B/metabolism*;
Phosphatidylinositol 3-Kinases/metabolism*;
Signal Transduction;
Transforming Growth Factor beta/metabolism*
- From:
Acta Physiologica Sinica
2022;74(3):495-504
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA-494 (miR-494) is a small non-coding RNA located in chromosome 14q32.31 and regulates post-transcriptional gene expression by promoting the degradation of its target mRNAs via binding to the 3' untranslated regions (3'UTR). It has been reported that miR-494 plays an important role in the occurrence, development and prognosis of various diseases. Several signaling pathways modulated by miR-494 including the PTEN/PI3K/AKT, nuclear factor κ-B (NF-κB), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β)/SMAD, and Wnt/β-catenin are associated with physiological regulation and pathological process in many diseases. The stably expression of miR-494 in the blood stream suggests its potential as a biological marker for disease diagnosis, treatment, and prognosis. Based on recent research, we summarize the role and molecular mechanism of miR-494 in disease development and progression. We also discuss its potential as a marker for clinical diagnosis and prognosis of various diseases.
