Neuroprotective effects of voluntary exercise and Yisaipu after traumatic brain injury in mice.
- Author:
Tian-Tian GAN
1
;
Qi LIAO
1
;
Ji-Hui WANG
1
;
Zhi-Heng FAN
1
;
Jian CAO
1
;
Hui-Ju PAN
1
;
Gao-Feng LOU
2
;
Xue-Fen DONG
1
;
Wei OUYANG
3
Author Information
1. College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua 321004, China.
2. Department of Endocrinology, Zhejiang Jinhua Guangfu Hospital, Jinhua 321004, China.
3. College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua 321004, China. wouyang@zjnu.cn.
- Publication Type:Randomized Controlled Trial, Veterinary
- MeSH:
Animals;
Brain Injuries, Traumatic/pathology*;
Disease Models, Animal;
Male;
Mice;
Mice, Inbred C57BL;
Neuroprotective Agents/pharmacology*;
Recovery of Function;
Tumor Necrosis Factor Inhibitors
- From:
Acta Physiologica Sinica
2022;74(3):333-352
- CountryChina
- Language:English
-
Abstract:
The mechanisms underlying exercise-induced neuroprotective effects after traumatic brain injury (TBI) remained elusive, and there is a lack of effective treatments for TBI. In this study, we investigated the effects of an integrative approach of exercise and Yisaipu (TNFR-IgG fusion protein, TNF inhibitor) in a mouse TBI model. Male C57BL/6J mice were randomly assigned to a sedentary group or a group that followed a voluntary exercise regimen. The effects of 6-week prophylactic preconditioning exercise (PE) alone or in combination with post-TBI Yisaipu treatment on moderate TBI associated deficits were examined. The results showed that combined treatments of PE and post-TBI Yisaipu were superior to single treatments on reducing sensorimotor and gait dysfunctions in mice. These functional improvements were accompanied by reduced systemic inflammation largely via decreased serum TNF-α, boosted autophagic flux, and mitigated lesion volume after TBI. Given these neuroprotective effects, composite approaches such as a combination of exercise and TNF inhibitor may be a promising strategy for facilitating functional recovery from TBI and are worth further investigation.
