Expression of Microtubule-associated Protein 1 Light Chain 3 II and Microtubule-associated Protein 2 in CA1 Area of Hippocampus of Vascular Dementia Rats
10.3969/j.issn.1006-9771.2015.05.001
- VernacularTitle:微管相关蛋白1轻链3Ⅱ与微管相关蛋白2 在血管性痴呆大鼠海马CA1 区的表达
- Author:
Xinxia LIU
;
Yuanyuan MA
;
Bin LIU
;
Chunying DENG
;
Shiying LI
- Publication Type:Journal Article
- Keywords:
vascular dementia, microtubule-associated protein 1 light chain 3, microtubule-associated protein 2, hippocampus, autophagy
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;21(5):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of microtubule-associated protein 1 light chain 3 II (LC3II) and microtubule-associated protein 2 (MAP-2) in CA1 area of hippocampus in vascular dementia rats. Methods 48 Sprague-Dawley rats were randomly divided into sham group and model group. Meanwhile, each group was further divided into 1, 2, 4 and 8 weeks subgroups (n=6). Vascular dementia model was established by blocking four vessels. The expressions of LC3II and MAP-2 protein were detected with immunohistochemistry in the CA1 area of hippocampus. Results The expression of LC3II significantly increased, and the expression of MAP-2 decreased in the model group compared with the sham group at every time point (P<0.001). The expression of LC3II was negatively correlated with MAP-2 at every time point in the model group (r=-0.723, P<0.05). Conclusion It may play an important role for the occurrence and development of vascular dementia that the expression of LC3II increased and MAP-2 descreased in CA1 area of hippocampus in rats.
