Distribution and Drug- resistance of Pathogens of Nosocomial Infection in Spinal Cord Injury: 395 Cases Report
10.3969/j.issn.1006-9771.2015.04.021
- VernacularTitle:395例脊髓损伤患者医院感染的病原菌分布和耐药情况分析
- Author:
Guowei ZHAO
;
Jun GAO
- Publication Type:Journal Article
- Keywords:
spinal cord injury, nosocomial infection, pathogens, antibiotic therapy
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;21(4):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To pave the way for clinical therapy and reasonable administration of antibiotics, and to analyze the kinds and drug-resistance of pathogens of nosocomial infection in patients with spinal cord injury. Methods Bacteriology of infection and drug resistance were analyzed in 395 patients with spinal cord injury in the hospital from Jun., 2012 to Dec., 2013. Results There were 132 cases with nosocomial infection. Most of the infections were found in urinary tract (71.1%) and lower respiratory tract (24.2%). The main pathogenic germs were Escherichia coli (45.6%), P. Aeruginosa (18.1%), K. pneumonia (11.4%) and P. mirabilis(8.7%), which were resistant to the second or third generation cephalosporins and quinolones moderately or severely, but sensitive to β-lactamase inhibitor combinations and aminoglycosides. Conclusion The main pathogenic bacteria in nosocomial infection of patients with spinal cord injury are G- bacilli. The bacteria are resistant moderately or severely to antibiotics, which should be selected rationally by bacterial culture and drug susceptibility test, and optimized rationally with PK/PD (pharmacokinetics and pharmacodynamics).
