Expression of Tumor Necrosis Factor-α and Interleukin-6 in Invasive Pituitary Adenoma

VernacularTitle:肿瘤坏死因子-α和白细胞介素-6在侵袭性垂体瘤中的表达
Author: Jianlong WU ; Jianyong QIAO ; Qinghua DUAN
Publication Type:Journal Article
Keywords: invasive pituitary adenoma, tumor necrosis factor-α, interleukin-6
From: Chinese Journal of Rehabilitation Theory and Practice 2015;21(4):432-435
CountryChina
Language:Chinese
Abstract: Objective To study the tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressed in invasive pituitary adenomas (IPA). Methods The expression of TNF-α and IL-6 were observed with immunohistochemstry (SP approach) in tissue from 40 cases of non-invasive pituitary adenomas (NIPA) and 40 cases of IPA. Results The expression of both TNF-α and IL-6 was significantly increased in the IPA tissues compared with those of NIPA (P<0.05). Conclusion TNF-α and IL-6 may play a role in the occurrence and development of IPA.